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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CIITA All Species: 11.82
Human Site: S280 Identified Species: 32.5
UniProt: P33076 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33076 NP_000237.2 1130 123443 S280 T V H G L P T S P D R P G S T
Chimpanzee Pan troglodytes Q53B87 1040 115280 G277 Q K S P A T L G L E E L F S T
Rhesus Macaque Macaca mulatta XP_001103518 1130 123636 S280 T V H G L P T S P D R P G S T
Dog Lupus familis XP_547128 1104 119761 A272 T S P F A P S A A D L P G M P
Cat Felis silvestris
Mouse Mus musculus P79621 1155 127510 S306 S I P S L P E S P D R P G S T
Rat Rattus norvegicus NP_445981 1153 127283 S306 T V P S L P E S P D R P G S T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516927 965 106480 F207 S G P G D R E F G V T W E S R
Chicken Gallus gallus XP_425250 824 93504 M66 E A F C T S L M D Y F R D V C
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001343072 1044 115802 Q270 M R G G M G M Q S H Y V D A H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.7 94.3 77.1 N.A. 61.3 61.3 N.A. 37.7 34.2 N.A. 32.1 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 35.2 96.6 84.3 N.A. 72.2 71.4 N.A. 52.1 47.4 N.A. 48.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 13.3 100 33.3 N.A. 66.6 80 N.A. 13.3 0 N.A. 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 20 100 46.6 N.A. 80 80 N.A. 20 0 N.A. 20 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 12 0 0 23 0 0 12 12 0 0 0 0 12 0 % A
% Cys: 0 0 0 12 0 0 0 0 0 0 0 0 0 0 12 % C
% Asp: 0 0 0 0 12 0 0 0 12 56 0 0 23 0 0 % D
% Glu: 12 0 0 0 0 0 34 0 0 12 12 0 12 0 0 % E
% Phe: 0 0 12 12 0 0 0 12 0 0 12 0 12 0 0 % F
% Gly: 0 12 12 45 0 12 0 12 12 0 0 0 56 0 0 % G
% His: 0 0 23 0 0 0 0 0 0 12 0 0 0 0 12 % H
% Ile: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 45 0 23 0 12 0 12 12 0 0 0 % L
% Met: 12 0 0 0 12 0 12 12 0 0 0 0 0 12 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 45 12 0 56 0 0 45 0 0 56 0 0 12 % P
% Gln: 12 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % Q
% Arg: 0 12 0 0 0 12 0 0 0 0 45 12 0 0 12 % R
% Ser: 23 12 12 23 0 12 12 45 12 0 0 0 0 67 0 % S
% Thr: 45 0 0 0 12 12 23 0 0 0 12 0 0 0 56 % T
% Val: 0 34 0 0 0 0 0 0 0 12 0 12 0 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 12 12 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _